Version 5.4
Homo sapiens Protein: CTSL2
Summary
InnateDB Protein IDBP-77611.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSL2
Protein Name cathepsin L2
Synonyms CATL2; CTSL2; CTSU;
Species Homo sapiens
Ensembl Protein ENSP00000259470
InnateDB Gene IDBG-77609 (CTSL2)
Protein Structure
UniProt Annotation
Function Cysteine protease. May have an important role in corneal physiology. {ECO:0000269PubMed:10029531, ECO:0000269PubMed:9727401}.
Subcellular Localization Lysosome {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. {ECO:0000269PubMed:10029531, ECO:0000269PubMed:9563472, ECO:0000269PubMed:9727401}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
PFAM PF00112
PF08246
PRINTS PR00705
PIRSF
SMART SM00645
SM00848
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60911
PhosphoSite PhosphoSite-O60911
TrEMBL A0A024R141
UniProt Splice Variant
Entrez Gene 1515
UniGene Hs.610096
RefSeq NP_001324
HUGO HGNC:2538
OMIM 603308
CCDS CCDS6723
HPRD 04495
IMGT
EMBL AB001928 AB019534 AF070448 AL445670 AY358641 BC023504 BC110512 CH471105 Y14734
GenPept AAC23598 AAH23504 AAI10513 AAQ89004 BAA25909 BAA34365 CAA75029 CAI15053 EAW58831 EAW58832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca