Version 5.4
Homo sapiens Protein: MAGT1
Summary
InnateDB Protein IDBP-77665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGT1
Protein Name magnesium transporter 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354649
InnateDB Gene IDBG-77663 (MAGT1)
Protein Structure
UniProt Annotation
Function May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells. {ECO:0000269PubMed:15804357, ECO:0000269PubMed:19717468}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19717468}; Multi-pass membrane protein {ECO:0000269PubMed:19717468}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN) [MIM:300853]: A disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation. {ECO:0000269PubMed:21796205}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Ubiquitous. Expressed at very low levels in brain, lung and kidney. {ECO:0000269PubMed:12887896, ECO:0000269PubMed:15804357, ECO:0000269PubMed:19717468}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015095 magnesium ion transmembrane transporter activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0015693 magnesium ion transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050890 cognition
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
IPR021149 Oligosaccharyl transferase complex, subunit OST3/OST6
PFAM PF13098
PF13192
PF13462
PF13905
PF04756
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0U3
PhosphoSite PhosphoSite-Q9H0U3
TrEMBL Q96SP2
UniProt Splice Variant
Entrez Gene 84061
UniGene Hs.323562
RefSeq
HUGO HGNC:28880
OMIM 300715
CCDS CCDS14436
HPRD 06487
IMGT
EMBL AK027632 AK075394 AK223131 AK314309 AL136636 AL138743 AL356235 AY358691 BC041014 BC060842 CH471104 DQ000004
GenPept AAH41014 AAH60842 AAQ89054 AAY18811 BAB55249 BAC11592 BAD96851 BAG36961 CAB66571 CAH70524 CAI39753 EAW98609 EAW98610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca