Version 5.4
Homo sapiens Protein: WFDC2
Summary
InnateDB Protein IDBP-77757.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC2
Protein Name WAP four-disulfide core domain 2
Synonyms dJ461P17.6; EDDM4; HE4; WAP5;
Species Homo sapiens
Ensembl Protein ENSP00000340215
InnateDB Gene IDBG-77751 (WFDC2)
Protein Structure
UniProt Annotation
Function Broad range protease inhibitor. {ECO:0000269PubMed:23139753}.
Subcellular Localization Secreted {ECO:0000269PubMed:15781627, ECO:0000269PubMed:23139753}.
Disease Associations
Tissue Specificity Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. {ECO:0000269PubMed:15781627}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
PFAM PF00095
PRINTS PR00003
PIRSF
SMART SM00217
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14508
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 10406
UniGene
RefSeq
HUGO HGNC:15939
OMIM
CCDS
HPRD 11684
IMGT
EMBL AF330259 AF330260 AF330261 AF330262 AL031663 AY212888 BC046106 CH471077 CR456977 X63187
GenPept AAH46106 AAL37485 AAL37486 AAL37487 AAL37488 AAO52683 CAA44869 CAB37641 CAG33258 CAM28246 CAM28247 CAO03535 EAW75836 EAW75837 EAW75839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca