Version 5.4
Homo sapiens Gene: WFDC2
Summary
InnateDB Gene IDBG-77751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC2
Gene Name WAP four-disulfide core domain 2
Synonyms dJ461P17.6; EDDM4; HE4; WAP5
Species Homo sapiens
Ensembl Gene ENSG00000101443
Encoded Proteins
IDBP-77753
WAP four-disulfide core domain 2
IDBP-77757
WAP four-disulfide core domain 2
IDBP-77759
WAP four-disulfide core domain 2
IDBP-77761
WAP four-disulfide core domain 2
IDBP-376425
WAP four-disulfide core domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45469706-45481532
Strand Forward strand
Band q13.12
Transcripts
ENST00000372676 ENSP00000361761
ENST00000339946 ENSP00000340215
ENST00000217425 ENSP00000217425
ENST00000342873 ENSP00000342890
ENST00000447118 ENSP00000404760
ENST00000462062
ENST00000488143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017723
View Gene Order
ENSBTAG00000013928
Not yet available
Cross-References
SwissProt Q14508
TrEMBL
UniProt Splice Variant
Entrez Gene 10406
UniGene
RefSeq NM_006103
HUGO HGNC:15939
OMIM
CCDS CCDS35501
HPRD 11684
IMGT
EMBL AF330259 AF330260 AF330261 AF330262 AL031663 AY212888 BC046106 CH471077 CR456977 X63187
GenPept AAH46106 AAL37485 AAL37486 AAL37487 AAL37488 AAO52683 CAA44869 CAB37641 CAG33258 CAM28246 CAM28247 CAO03535 EAW75836 EAW75837 EAW75839
RNA Seq Atlas 10406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca