InnateDB Protein
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IDBP-7781.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NOP14
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Protein Name
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NOP14 nucleolar protein homolog (yeast)
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Synonyms
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C4orf9; NOL14; RES425; UTP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315674
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InnateDB Gene
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IDBG-7779 (NOP14)
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Protein Structure
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Function |
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000447
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endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0000462
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maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0000472
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endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0000480
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endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0006364
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rRNA processing
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GO:0042274
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ribosomal small subunit biogenesis
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Cellular Component |
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PDB ID |
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InterPro |
IPR007276
Nucleolar protein 14
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PFAM |
PF04147
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P78316
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PhosphoSite |
PhosphoSite-P78316
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8602
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UniGene |
Hs.627133
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RefSeq |
NP_003694
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HUGO |
HGNC:16821
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OMIM |
611526
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CCDS |
CCDS33945
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HPRD |
12827
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IMGT |
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EMBL |
AB000467
AF040965
BC026035
BC053635
CH471131
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GenPept |
AAB97011
AAH26035
AAH53635
BAA19121
EAW82489
EAW82491
EAW82492
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