Version 5.4
Homo sapiens Protein: HSPE1
Summary
InnateDB Protein IDBP-78007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPE1
Protein Name heat shock 10kDa protein 1 (chaperonin 10)
Synonyms CPN10; EPF; GROES; HSP10;
Species Homo sapiens
Ensembl Protein ENSP00000233893
InnateDB Gene IDBG-78005 (HSPE1)
Protein Structure
UniProt Annotation
Function Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 38 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006457 protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011032 GroES (chaperonin 10)-like
IPR020818 Chaperonin Cpn10
PFAM PF00166
PRINTS PR00297
PIRSF
SMART SM00883
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61604
PhosphoSite PhosphoSite-P61604
TrEMBL Q9UNM1
UniProt Splice Variant
Entrez Gene 3336
UniGene Hs.689448
RefSeq NP_002148
HUGO HGNC:5269
OMIM 600141
CCDS CCDS2320
HPRD 02535
IMGT
EMBL AC020550 AF109872 AH007060 AJ250915 AK312104 BC023518 CH471063 CR407688 U07550 X75821
GenPept AAA50953 AAC95387 AAC96332 AAH23518 AAX93146 BAG35040 CAA53455 CAB75425 CAG28616 EAW70157 EAW70158 EAW70163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca