Version 5.4
Homo sapiens Gene: HSPE1
Summary
InnateDB Gene IDBG-78005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPE1
Gene Name heat shock 10kDa protein 1 (chaperonin 10)
Synonyms CPN10; EPF; GROES; HSP10
Species Homo sapiens
Ensembl Gene ENSG00000115541
Encoded Proteins
IDBP-78007
heat shock 10kDa protein 1 (chaperonin 10)
IDBP-293219
heat shock 10kDa protein 1 (chaperonin 10)
IDBP-293218
heat shock 10kDa protein 1 (chaperonin 10)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:197499994-197503457
Strand Forward strand
Band q33.1
Transcripts
ENST00000233893 ENSP00000233893
ENST00000409729 ENSP00000387101
ENST00000409468 ENSP00000386447
ENST00000473395
ENST00000495200
ENST00000465573
ENST00000463841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 38 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006457 protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006950 response to stress
GO:0006986 response to unfolded protein
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073676
View Gene Order
ENSBTAG00000012589
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591468 Hs.689448
RefSeq NM_002157
HUGO
OMIM
CCDS CCDS2320
HPRD 02535
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca