InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2C

Summary

InnateDB Protein

IDBP-78084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2C

Protein Name

ubiquitin-conjugating enzyme E2C

Synonyms

dJ447F3.2; UBCH10;

Species

Homo sapiens

Ensembl Protein

ENSP00000348838

InnateDB Gene

IDBG-78076 (UBE2C)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269PubMed:15558010, ECO:0000269PubMed:18485873, ECO:0000269PubMed:19820702, ECO:0000269PubMed:19822757, ECO:0000269PubMed:20061386}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	73 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007094	mitotic spindle assembly checkpoint
GO:0008054	cyclin catabolic process
GO:0010458	exit from mitosis
GO:0010994	free ubiquitin chain polymerization
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031536	positive regulation of exit from mitosis
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488	activation of anaphase-promoting complex activity
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination