InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NANS

Summary

InnateDB Protein

IDBP-78127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NANS

Protein Name

N-acetylneuraminic acid synthase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000210444

InnateDB Gene

IDBG-78125 (NANS)

Protein Structure

UniProt Annotation

Function

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008781	N-acylneuraminate cytidylyltransferase activity
GO:0047444	N-acylneuraminate-9-phosphate synthase activity
GO:0050462	N-acetylneuraminate synthase activity

Biological Process

GO:0009103	lipopolysaccharide biosynthetic process
GO:0016051	carbohydrate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006013 Antifreeze, type III
IPR006190 Antifreeze-like/N-acetylneuraminic acid synthase C-terminal
IPR013132 N-acetylneuraminic acid synthase, N-terminal
IPR013974 SAF domain

PFAM

PF03102
PF08666
PF13144

PRINTS

PR00357

PIRSF

SMART

SM00858

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt