InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIF1

Summary

InnateDB Protein

IDBP-78200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIF1

Protein Name

allograft inflammatory factor 1

Synonyms

AIF-1; IBA1; IRT-1; IRT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365217

InnateDB Gene

IDBG-78190 (AIF1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269PubMed:15117732, ECO:0000269PubMed:16049345, ECO:0000269PubMed:18699778}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Disease Associations

Tissue Specificity

Detected in T-lymphocytes and peripheral blood mononuclear cells. {ECO:0000269PubMed:16049345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding
GO:0051015	actin filament binding

Biological Process

GO:0001774	microglial cell activation
GO:0006911	phagocytosis, engulfment
GO:0006954	inflammatory response
GO:0016601	Rac protein signal transduction
GO:0030041	actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051017	actin filament bundle assembly
GO:0071346	cellular response to interferon-gamma
GO:0071672	negative regulation of smooth muscle cell chemotaxis
GO:0071673	positive regulation of smooth muscle cell chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis
GO:0097178	ruffle assembly
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0030027	lamellipodium
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm