Version 5.4
Homo sapiens Gene: AIF1
Summary
InnateDB Gene IDBG-78190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIF1
Gene Name allograft inflammatory factor 1
Synonyms AIF-1; IBA1; IRT-1; IRT1
Species Homo sapiens
Ensembl Gene ENSG00000204472
Encoded Proteins
IDBP-78194
allograft inflammatory factor 1
IDBP-78196
allograft inflammatory factor 1
IDBP-78200
allograft inflammatory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31615184-31617021
Strand Forward strand
Band p21.33
Transcripts
ENST00000376059 ENSP00000365227
ENST00000337917 ENSP00000338776
ENST00000376049 ENSP00000365217
ENST00000497362
ENST00000466820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0006911 phagocytosis, engulfment
GO:0006954 inflammatory response
GO:0010629 negative regulation of gene expression
GO:0014739 positive regulation of muscle hyperplasia
GO:0016601 Rac protein signal transduction
GO:0030041 actin filament polymerization
GO:0030335 positive regulation of cell migration
GO:0031668 cellular response to extracellular stimulus
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0042102 positive regulation of T cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048678 response to axon injury
GO:0051017 actin filament bundle assembly
GO:0051602 response to electrical stimulus
GO:0071315 cellular response to morphine
GO:0071346 cellular response to interferon-gamma
GO:0071447 cellular response to hydroperoxide
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
GO:0097178 ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024397
View Gene Order
ENSBTAG00000020554
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.608968
RefSeq NM_001623 NM_004847 NM_032955 XM_005248871 XM_005272779 XM_005274925 XM_005275221 XM_005275357 XM_005275516
HUGO
OMIM
CCDS CCDS34398 CCDS4706
HPRD 03496
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca