InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AOX1

Summary

InnateDB Protein

IDBP-78224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AOX1

Protein Name

aldehyde oxidase 1

Synonyms

AO; AOH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363832

InnateDB Gene

IDBG-78222 (AOX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004031	aldehyde oxidase activity
GO:0004854	xanthine dehydrogenase activity
GO:0005506	iron ion binding
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0043546	molybdopterin cofactor binding
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051287	NAD binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006954	inflammatory response
GO:0042816	vitamin B6 metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR001041 2Fe-2S ferredoxin-type domain
IPR002346 Molybdopterin dehydrogenase, FAD-binding
IPR002888 [2Fe-2S]-binding
IPR005107 CO dehydrogenase flavoprotein, C-terminal
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
IPR014313 Aldehyde oxidase
IPR016166 FAD-binding, type 2
IPR016208 Aldehyde oxidase/xanthine dehydrogenase

PFAM

PF01315
PF00111
PF00941
PF01799
PF03450
PF02738

PRINTS

PIRSF

PIRSF000127

SMART

SM01008
SM01092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt