Version 5.4
Homo sapiens Protein: HMGN5
Summary
InnateDB Protein IDBP-78262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN5
Protein Name high mobility group nucleosome binding domain 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350848
InnateDB Gene IDBG-78260 (HMGN5)
Protein Structure
UniProt Annotation
Function Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11161810}. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11161810}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
PFAM PF01101
PRINTS PR00925
PIRSF
SMART SM00527
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P82970
PhosphoSite PhosphoSite-P82970
TrEMBL Q5JSL0
UniProt Splice Variant
Entrez Gene 79366
UniGene Hs.282204
RefSeq NP_110390
HUGO HGNC:8013
OMIM 300385
CCDS CCDS14448
HPRD 02310
IMGT
EMBL AF250329 AF250330 AK094058 AL357115 AL391294 AL590810 BC005342 CH471104
GenPept AAH05342 AAK14062 AAK14063 CAI39708 EAW98582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca