InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIL3

Summary

InnateDB Protein

IDBP-78290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIL3

Protein Name

peptidylprolyl isomerase (cyclophilin)-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286175

InnateDB Gene

IDBG-409196 (PPIL3)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Detected at low levels. {ECO:0000269PubMed:11435694}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding

Cellular Component

GO:0071013

catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR029000 Cyclophilin-like domain

PFAM

PF00160

PRINTS

PR00153

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H2H8

PhosphoSite

PhosphoSite-Q9H2H8

TrEMBL

UniProt Splice Variant

Entrez Gene

53938

UniGene

Hs.599602

RefSeq

NP_115861

HUGO

HGNC:9262

OMIM

615811

CCDS

CCDS2332

HPRD

15163

IMGT

EMBL

AC005037 AF146799 AF251049 AF271652 AK027315 BC007693

GenPept

AAG44766 AAH07693 AAK34939 AAO64723 AAY14723 BAB55036