InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABBR2

Summary

InnateDB Protein

IDBP-78323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABBR2

Protein Name

gamma-aminobutyric acid (GABA) B receptor, 2

Synonyms

GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099;

Species

Homo sapiens

Ensembl Protein

ENSP00000259455

InnateDB Gene

IDBG-78321 (GABBR2)

Protein Structure

UniProt Annotation

Function

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. {ECO:0000269PubMed:10328880, ECO:0000269PubMed:18165688, ECO:0000269PubMed:22660477, ECO:0000269PubMed:24305054, ECO:0000269PubMed:9872316}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.

Disease Associations

Tissue Specificity

Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. {ECO:0000269PubMed:10087195, ECO:0000269PubMed:10328880, ECO:0000269PubMed:10727622}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004965	G-protein coupled GABA receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0038039	G-protein coupled receptor heterodimeric complex
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000337 GPCR, family 3
IPR001828 Extracellular ligand-binding receptor
IPR002456 GPCR, family 3, gamma-aminobutyric acid receptor, type B1
IPR002457 GPCR, family 3, gamma-aminobutyric acid receptor, type B2
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF00003

PRINTS

PR00248
PR01177
PR01178

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75899