Version 5.4
Homo sapiens Protein: NEURL2
Summary
InnateDB Protein IDBP-78408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEURL2
Protein Name neuralized homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361596
InnateDB Gene IDBG-78406 (NEURL2)
Protein Structure
UniProt Annotation
Function Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed specifically in skeletal and cardiac muscles. {ECO:0000269PubMed:14960280}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030239 myofibril assembly
GO:0035556 intracellular signal transduction
GO:0045214 sarcomere organization
Cellular Component
GO:0005927 muscle tendon junction
GO:0030891 VCB complex
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR006573 NEUZ domain
PFAM PF07525
PF07177
PRINTS
PIRSF
SMART SM00253
SM00969
SM00588
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BR09
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 140825
UniGene Hs.517094
RefSeq NP_542787
HUGO HGNC:16156
OMIM 608597
CCDS CCDS13384
HPRD 16353
IMGT
EMBL AJ295985 AK054821 AL008726 BC074737 BC105935 BC107485
GenPept AAH74737 AAI05936 AAI07486 BAB70810 CAC36018 CAC82498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca