Version 5.4
Homo sapiens Protein: COL15A1
Summary
InnateDB Protein IDBP-78447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL15A1
Protein Name collagen, type XV, alpha 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364140
InnateDB Gene IDBG-78445 (COL15A1)
Protein Structure
UniProt Annotation
Function Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269PubMed:10049780}.Restin potently inhibits angiogenesis. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005582 collagen type XV
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001791 Laminin G domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010515 Collagenase NC10/endostatin
IPR016187 C-type lectin fold
PFAM PF00054
PF02210
PF01391
PF06482
PRINTS
PIRSF
SMART SM00210
SM00282
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P39059
PhosphoSite PhosphoSite-P39059
TrEMBL
UniProt Splice Variant
Entrez Gene 1306
UniGene Hs.733201
RefSeq NP_001846
HUGO HGNC:2192
OMIM 120325
CCDS CCDS35081
HPRD 00380
IMGT
EMBL AF052956 AF052957 AF052958 AF052959 AF052960 AF052961 AF052962 AF052963 AF052964 AF052965 AF052966 AF052967 AF052968 AF052969 AF052970 AF052971 AF052972 AF052973 AF052974 AF052975 AL136084 AL354923 D21230 L01697 L25280 L25281 L25282 L25283 L25284 L25285 L25286
GenPept AAA58429 AAC78500 BAA04762 CAI12548 CAI17044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca