InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KA6

Summary

InnateDB Protein

IDBP-78454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA6

Protein Name

ribosomal protein S6 kinase, 90kDa, polypeptide 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262752

InnateDB Gene

IDBG-78452 (RPS6KA6)

Protein Structure

UniProt Annotation

Function

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269PubMed:15042092, ECO:0000269PubMed:15632195}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:15632195}. Nucleus {ECO:0000269PubMed:15632195}. Note=Predominantly cytosolic.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0035556	intracellular signal transduction
GO:0045992	negative regulation of embryonic development
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000381	negative regulation of mesoderm development

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References