InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSNK2B

Summary

InnateDB Protein

IDBP-78587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK2B

Protein Name

casein kinase 2, beta polypeptide

Synonyms

CK2B; CK2N; CSK2B; G5A;

Species

Homo sapiens

Ensembl Protein

ENSP00000365025

InnateDB Gene

IDBG-78569 (CSNK2B)

Protein Structure

UniProt Annotation

Function

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. {ECO:0000250, ECO:0000269PubMed:11239457, ECO:0000269PubMed:16818610}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	365 [view]
Protein-Protein	362 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019887	protein kinase regulator activity
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0033211	adiponectin-activated signaling pathway
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043623	cellular protein complex assembly
GO:0045859	regulation of protein kinase activity
GO:0051101	regulation of DNA binding
GO:0061154	endothelial tube morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005956	protein kinase CK2 complex
GO:0031519	PcG protein complex
GO:0070062	extracellular vesicular exosome