Version 5.4
Homo sapiens Protein: DACH2
Summary
InnateDB Protein IDBP-78673.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DACH2
Protein Name dachshund homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362223
InnateDB Gene IDBG-78671 (DACH2)
Protein Structure
UniProt Annotation
Function Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003380 Transforming protein Ski
IPR009061 DNA binding domain, putative
PFAM PF02437
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NX9
PhosphoSite PhosphoSite-Q96NX9
TrEMBL B4DIK6
UniProt Splice Variant
Entrez Gene 117154
UniGene Hs.86603
RefSeq NP_001132986
HUGO HGNC:16814
OMIM 300608
CCDS CCDS48140
HPRD 06481
IMGT
EMBL AF428101 AK055953 AK091842 AK295648 AK298787 AL023095 AL034406 AL109752 AL138747 AL157381 AL390058 AL591465 AL834456 Z95124 Z95325
GenPept AAL26561 BAB71054 BAC03761 BAG58518 BAG60925 CAD39116 CAI40274 CAI42168 CAI42587 CAI42954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca