Version 5.4
Homo sapiens Gene: DACH2
Summary
InnateDB Gene IDBG-78671.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DACH2
Gene Name dachshund homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126733
Encoded Proteins
IDBP-78673
dachshund homolog 2 (Drosophila)
IDBP-78677
dachshund homolog 2 (Drosophila)
IDBP-478881
dachshund homolog 2 (Drosophila)
IDBP-475789
dachshund homolog 2 (Drosophila)
IDBP-474552
dachshund homolog 2 (Drosophila)
IDBP-478544
dachshund homolog 2 (Drosophila)
IDBP-483188
dachshund homolog 2 (Drosophila)
IDBP-810314
dachshund family transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:86148458-86832604
Strand Forward strand
Band q21.2
Transcripts
ENST00000373131 ENSP00000362223
ENST00000373125 ENSP00000362217
ENST00000461604 ENSP00000421509
ENST00000506327 ENSP00000426837
ENST00000508860 ENSP00000420896
ENST00000510272 ENSP00000421919
ENST00000484479 ENSP00000422727
ENST00000613770 ENSP00000478116
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0046545 development of primary female sexual characteristics
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025592
View Gene Order
ENSBTAG00000044037
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626296 Hs.86603
RefSeq NM_001139514 NM_001139515 NM_053281 XM_005262068
HUGO
OMIM
CCDS CCDS14455 CCDS48140 CCDS55457
HPRD 06481
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca