InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP9

Summary

InnateDB Protein

IDBP-78724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP9

Protein Name

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Synonyms

CLG4B; GELB; MANDP2; MMP-9;

Species

Homo sapiens

Ensembl Protein

ENSP00000361405

InnateDB Gene

IDBG-78722 (MMP9)

Protein Structure

UniProt Annotation

Function

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly--Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000269PubMed:1480034}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Produced by normal alveolar macrophages and granulocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	26 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0006508	proteolysis
GO:0007566	embryo implantation
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030225	macrophage differentiation
GO:0030574	collagen catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0051549	positive regulation of keratinocyte migration
GO:1900122	positive regulation of receptor binding
GO:2001258	negative regulation of cation channel activity

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR006970 PT repeat
IPR013806 Kringle-like fold
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00040
PF00413
PF01471
PF04886
PF00045

PRINTS

PR00138

PIRSF

SMART

SM00059
SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt