Version 5.4
Mus musculus Protein: Prkce
Summary
InnateDB Protein IDBP-787780.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkce
Protein Name protein kinase C, epsilon
Synonyms 5830406C15Rik; PKC[e]; Pkce; PKCepsilon; R75156;
Species Mus musculus
Ensembl Protein ENSMUSP00000138615
InnateDB Gene IDBG-201164 (Prkce)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0004699 calcium-independent protein kinase C activity
GO:0005515 protein binding
GO:0030546 receptor activator activity
GO:0035276 ethanol binding
Biological Process
GO:0002281 macrophage activation involved in immune response
GO:0006468 protein phosphorylation
GO:0007635 chemosensory behavior
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019216 regulation of lipid metabolic process
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035641 locomotory exploration behavior
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278 response to morphine
GO:0043410 positive regulation of MAPK cascade
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050996 positive regulation of lipid catabolic process
GO:0051209 release of sequestered calcium ion into cytosol
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070257 positive regulation of mucus secretion
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:97599
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8C944
UniProt Splice Variant
Entrez Gene 18754
UniGene
RefSeq
MGI ID
MGI Symbol Prkce
OMIM
CCDS
HPRD
IMGT
EMBL AC096777 AC154236 AC154351 AC154542 AK042994 CT030001
GenPept BAC31430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca