InnateDB Protein
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IDBP-78785.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C6orf25
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Protein Name
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chromosome 6 open reading frame 25
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364972
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InnateDB Gene
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IDBG-78777 (C6orf25)
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Protein Structure
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Function |
Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. {ECO:0000269PubMed:17311996}.
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Subcellular Localization |
Isoform E: Endoplasmic reticulum. Golgi apparatus.Isoform D: Endoplasmic reticulum. Golgi apparatus.Isoform B: Cell membrane; Single-pass type I membrane protein.Isoform A: Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets. {ECO:0000269PubMed:11544253, ECO:0000269PubMed:17311996}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95866
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PhosphoSite |
PhosphoSite-O95866
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80739
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UniGene |
Hs.247879
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RefSeq |
NP_612119
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HUGO |
HGNC:13937
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OMIM |
606520
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CCDS |
CCDS34405
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HPRD |
09405
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IMGT |
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EMBL |
AF129756
AJ292259
AJ292260
AJ292261
AJ292262
AJ292263
AJ292264
AJ292265
AL662899
AL670886
AL844216
BA000025
BC113719
BC113721
BX248244
CH471081
CR354443
CR759787
CR936239
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GenPept |
AAD18075
AAI13720
AAI13722
BAB63378
CAC83496
CAC83497
CAC83498
CAC83499
CAC83500
CAC83501
CAC83502
CAI17813
CAI17814
CAI17815
CAI17816
CAI17818
CAI18406
CAI18407
CAI18408
CAI18409
CAI18412
CAM26092
CAM26093
CAM26094
CAM26095
CAM26096
CAM45767
CAM45768
CAM45769
CAM45770
CAM45771
CAQ07017
CAQ07020
CAQ07021
CAQ08890
CAQ08892
CAQ08893
CAQ08894
CAQ10105
CAQ10107
CAQ10108
CAQ10109
EAX03493
EAX03494
EAX03497
EAX03498
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