Version 5.4
Homo sapiens Protein: C6orf25
Summary
InnateDB Protein IDBP-78787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6orf25
Protein Name chromosome 6 open reading frame 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364964
InnateDB Gene IDBG-78777 (C6orf25)
Protein Structure
UniProt Annotation
Function Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. {ECO:0000269PubMed:17311996}.
Subcellular Localization Isoform E: Endoplasmic reticulum. Golgi apparatus.Isoform D: Endoplasmic reticulum. Golgi apparatus.Isoform B: Cell membrane; Single-pass type I membrane protein.Isoform A: Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets. {ECO:0000269PubMed:11544253, ECO:0000269PubMed:17311996}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0030220 platelet formation
GO:0035855 megakaryocyte development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95866
PhosphoSite PhosphoSite-O95866
TrEMBL
UniProt Splice Variant
Entrez Gene 80739
UniGene Hs.247879
RefSeq NP_612116
HUGO HGNC:13937
OMIM 606520
CCDS CCDS4715
HPRD 09405
IMGT
EMBL AF129756 AJ292259 AJ292260 AJ292261 AJ292262 AJ292263 AJ292264 AJ292265 AL662899 AL670886 AL844216 BA000025 BC113719 BC113721 BX248244 CH471081 CR354443 CR759787 CR936239
GenPept AAD18075 AAI13720 AAI13722 BAB63378 CAC83496 CAC83497 CAC83498 CAC83499 CAC83500 CAC83501 CAC83502 CAI17813 CAI17814 CAI17815 CAI17816 CAI17818 CAI18406 CAI18407 CAI18408 CAI18409 CAI18412 CAM26092 CAM26093 CAM26094 CAM26095 CAM26096 CAM45767 CAM45768 CAM45769 CAM45770 CAM45771 CAQ07017 CAQ07020 CAQ07021 CAQ08890 CAQ08892 CAQ08893 CAQ08894 CAQ10105 CAQ10107 CAQ10108 CAQ10109 EAX03493 EAX03494 EAX03497 EAX03498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca