InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDAH2

Summary

InnateDB Protein

IDBP-78864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDAH2

Protein Name

dimethylarginine dimethylaminohydrolase 2

Synonyms

DDAH; DDAHII; G6a; HEL-S-277; NG30;

Species

Homo sapiens

Ensembl Protein

ENSP00000364945

InnateDB Gene

IDBG-238590 (DDAH2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269PubMed:10493931}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21898353}. Mitochondrion {ECO:0000269PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.

Disease Associations

Tissue Specificity

Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269PubMed:10493931}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016403	dimethylargininase activity
GO:0016597	amino acid binding
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0000052	citrulline metabolic process
GO:0006525	arginine metabolic process
GO:0006527	arginine catabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process