Version 5.4
Homo sapiens Gene: DDAH2
Summary
InnateDB Gene IDBG-238590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDAH2
Gene Name dimethylarginine dimethylaminohydrolase 2
Synonyms DDAH; DDAHII; G6a; HEL-S-277; NG30
Species Homo sapiens
Ensembl Gene ENSG00000213722
Encoded Proteins
IDBP-78862
dimethylarginine dimethylaminohydrolase 2
IDBP-78864
dimethylarginine dimethylaminohydrolase 2
IDBP-78866
dimethylarginine dimethylaminohydrolase 2
IDBP-372470
dimethylarginine dimethylaminohydrolase 2
IDBP-372478
dimethylarginine dimethylaminohydrolase 2
IDBP-372483
dimethylarginine dimethylaminohydrolase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31727038-31730617
Strand Reverse strand
Band p21.33
Transcripts
ENST00000375792 ENSP00000364949
ENST00000375789 ENSP00000364945
ENST00000375787 ENSP00000364943
ENST00000437288 ENSP00000413164
ENST00000416410 ENSP00000397466
ENST00000436437 ENSP00000395759
ENST00000469963
ENST00000480913
ENST00000483792
ENST00000488119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Biological Process
GO:0000052 citrulline metabolic process
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007039
View Gene Order
ENSBTAG00000013530
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_013974
HUGO
OMIM
CCDS CCDS4718
HPRD 09204
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca