InnateDB Protein
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IDBP-78866.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DDAH2
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Protein Name
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dimethylarginine dimethylaminohydrolase 2
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Synonyms
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DDAH; DDAHII; G6a; HEL-S-277; NG30;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364943
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InnateDB Gene
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IDBG-238590 (DDAH2)
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Protein Structure
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Function |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269PubMed:10493931}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:21898353}. Mitochondrion {ECO:0000269PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
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Disease Associations |
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Tissue Specificity |
Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269PubMed:10493931}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003824
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catalytic activity
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GO:0005515
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protein binding
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GO:0016403
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dimethylargininase activity
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GO:0016813
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003198
Amidinotransferase
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PFAM |
PF02274
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95865
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PhosphoSite |
PhosphoSite-O95865
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TrEMBL |
V9HW53
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UniProt Splice Variant |
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Entrez Gene |
23564
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UniGene |
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RefSeq |
NP_039268
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HUGO |
HGNC:2716
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OMIM |
604744
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CCDS |
CCDS4718
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HPRD |
09204
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IMGT |
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EMBL |
AF070667
AF087894
AF129756
AJ012008
AL662899
AL670886
AL844216
BA000025
BC001435
BX248244
CH471081
CR354443
CR759787
CR936239
FJ224290
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GenPept |
AAD18074
AAD20973
AAH01435
AAP97193
ACI45982
BAB63377
CAB46079
CAI17820
CAI18413
CAM26098
CAM45772
CAQ07022
CAQ08895
CAQ10110
EAX03500
EAX03501
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