Version 5.4
Mus musculus Protein: Rnasel
Summary
InnateDB Protein IDBP-788677.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnasel
Protein Name ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Synonyms E230029I04Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000138734
InnateDB Gene IDBG-199298 (Rnasel)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0045071 negative regulation of viral genome replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0090501 RNA phosphodiester bond hydrolysis
Cellular Component
GO:0005739 mitochondrion
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID MGI:1098272
InterPro IPR006567 PUG domain
IPR010513 KEN domain
PFAM PF06479
PRINTS
PIRSF
SMART SM00580
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05921
PhosphoSite PhosphoSite-Q05921
TrEMBL Q3T9T6
UniProt Splice Variant
Entrez Gene 24014
UniGene
RefSeq
MGI ID
MGI Symbol Rnasel
OMIM
CCDS
HPRD
IMGT
EMBL AC154140 AF281045 AK172300 L10382
GenPept AAA37117 AAG33708 BAE42934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca