InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3cb

Summary

InnateDB Protein

IDBP-788691.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3cb

Protein Name

phosphatidylinositol 3-kinase, catalytic, beta polypeptide

Synonyms

1110001J02Rik; AI447572; p110beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000138346

InnateDB Gene

IDBG-192637 (Pik3cb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560	insulin receptor substrate binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process

GO:0001952	regulation of cell-matrix adhesion
GO:0006874	cellular calcium ion homeostasis
GO:0007156	homophilic cell adhesion
GO:0030168	platelet activation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0040016	embryonic cleavage
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex

Protein Structure and Domains

PDB ID

MGI:1922019

InterPro

IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00794
PF00792
PF02192

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00144
SM00142
SM00143

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

S4R1S1

UniProt Splice Variant

Entrez Gene

74769

UniGene

RefSeq

MGI ID

MGI Symbol

Pik3cb

OMIM

CCDS

HPRD

IMGT

EMBL

AC120148 AC122930

GenPept