InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAU

Summary

InnateDB Protein

IDBP-78891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAU

Protein Name

plasminogen activator, urokinase

Synonyms

ATF; BDPLT5; QPD; u-PA; UPA; URK;

Species

Homo sapiens

Ensembl Protein

ENSP00000361850

InnateDB Gene

IDBG-78889 (PLAU)

Protein Structure

UniProt Annotation

Function

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Subcellular Localization

Secreted.

Disease Associations

Quebec platelet disorder (QPD) [MIM:601709]: An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. {ECO:0000269PubMed:20007542}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the prostate gland and prostate cancers. {ECO:0000269PubMed:15988036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010469	regulation of receptor activity
GO:0014909	smooth muscle cell migration
GO:0014910	regulation of smooth muscle cell migration
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0042127	regulation of cell proliferation
GO:0042730	fibrinolysis
GO:0061041	regulation of wound healing
GO:2000097	regulation of smooth muscle cell-matrix adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00008
PF00089

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00181
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt