Version 5.4
Mus musculus Protein: Terf1
Summary
InnateDB Protein IDBP-788997.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Terf1
Protein Name telomeric repeat binding factor 1
Synonyms Pin2; Trbf1; Trf1;
Species Mus musculus
Ensembl Protein ENSMUSP00000140744
InnateDB Gene IDBG-134893 (Terf1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 276 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 276 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003691 double-stranded telomeric DNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008301 DNA binding, bending
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010521 telomerase inhibitor activity
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000723 telomere maintenance
GO:0001309 age-dependent telomere shortening
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007067 mitotic nuclear division
GO:0007094 mitotic spindle assembly checkpoint
GO:0008156 negative regulation of DNA replication
GO:0010834 telomere maintenance via telomere shortening
GO:0031116 positive regulation of microtubule polymerization
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045840 positive regulation of mitosis
GO:0045931 positive regulation of mitotic cell cycle
GO:0051260 protein homooligomerization
GO:0051974 negative regulation of telomerase activity
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
Protein Structure and Domains
PDB ID MGI:109634
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR013867 Telomere repeat-binding factor, dimerisation domain
IPR017357 Telomeric repeat-binding factor 1/2
IPR017877 Myb-like domain
PFAM PF00249
PF08558
PRINTS
PIRSF PIRSF038016
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 21749
UniGene
RefSeq NP_033378
MGI ID
MGI Symbol Terf1
OMIM
CCDS CCDS14827
HPRD
IMGT
EMBL AK021235 BC034866 U65586 U70994
GenPept AAB17974 AAB53970 AAH34866 BAB32340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca