InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrm3

Summary

InnateDB Protein

IDBP-789190.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrm3

Protein Name

cholinergic receptor, muscarinic 3, cardiac

Synonyms

Chrm-3; M3; M3R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000140131

InnateDB Gene

IDBG-129548 (Chrm3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015464	acetylcholine receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0003056	regulation of vascular smooth muscle contraction
GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007271	synaptic transmission, cholinergic
GO:0007586	digestion
GO:0019229	regulation of vasoconstriction
GO:0043087	regulation of GTPase activity
GO:0045987	positive regulation of smooth muscle contraction
GO:0046541	saliva secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0043679	axon terminus
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:88398

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR001183 Muscarinic acetylcholine receptor M3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00243
PR00540

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite