Version 5.4
Mus musculus Protein: Adm
Summary
InnateDB Protein IDBP-789209.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adm
Protein Name adrenomedullin
Synonyms AM;
Species Mus musculus
Ensembl Protein ENSMUSP00000140890
InnateDB Gene IDBG-206620 (Adm)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031700 adrenomedullin receptor binding
Biological Process
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0002026 regulation of the force of heart contraction
GO:0002031 G-protein coupled receptor internalization
GO:0006171 cAMP biosynthetic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008209 androgen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010460 positive regulation of heart rate
GO:0019933 cAMP-mediated signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031100 organ regeneration
GO:0031102 neuron projection regeneration
GO:0031623 receptor internalization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0046879 hormone secretion
GO:0048589 developmental growth
GO:0051384 response to glucocorticoid
GO:0055074 calcium ion homeostasis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:108058
InterPro IPR001710 Adrenomedullin
IPR021116 Procalcitonin/adrenomedullin
PFAM PF00214
PRINTS PR00801
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11535
UniGene
RefSeq
MGI ID
MGI Symbol Adm
OMIM
CCDS
HPRD
IMGT
EMBL AK144181 AK144600 AK144649 AK171066 BC052665 CH466531 D78349 U77630
GenPept AAB36535 AAH52665 BAA11367 BAE25751 BAE25959 BAE25989 BAE42225 EDL16987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca