InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adm

Summary

InnateDB Gene

IDBG-206620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adm

Gene Name

adrenomedullin

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030790

Encoded Proteins

IDBP-206622

adrenomedullin

IDBP-789209

adrenomedullin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148926:
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:110627661-110629820

Strand

Forward strand

Band

Transcripts

ENSMUST00000033054	ENSMUSP00000033054
ENSMUST00000186620	ENSMUSP00000140890
ENSMUST00000185766

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031700	adrenomedullin receptor binding

Biological Process

GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001843	neural tube closure
GO:0002026	regulation of the force of heart contraction
GO:0002031	G-protein coupled receptor internalization
GO:0006171	cAMP biosynthetic process
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007568	aging
GO:0008209	androgen metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009409	response to cold
GO:0009611	response to wounding
GO:0010033	response to organic substance
GO:0010460	positive regulation of heart rate
GO:0019933	cAMP-mediated signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031100	organ regeneration
GO:0031102	neuron projection regeneration
GO:0031623	receptor internalization
GO:0032496	response to lipopolysaccharide
GO:0032868	response to insulin
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0045766	positive regulation of angiogenesis
GO:0045906	negative regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0046879	hormone secretion
GO:0048589	developmental growth
GO:0051384	response to glucocorticoid
GO:0055074	calcium ion homeostasis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060712	spongiotrophoblast layer development
GO:0097084	vascular smooth muscle cell development
GO:2001214	positive regulation of vasculogenesis