InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tie1

Summary

InnateDB Protein

IDBP-789247.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tie1

Protein Name

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Synonyms

D430008P04Rik; TIE; tie-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139279

InnateDB Gene

IDBG-181621 (Tie1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0016525	negative regulation of angiogenesis
GO:0030336	negative regulation of cell migration
GO:0045026	plasma membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99906

InterPro

IPR000742 Epidermal growth factor-like domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013111 EGF-like domain, extracellular
IPR013151 Immunoglobulin

PFAM

PF00008
PF00041
PF01108
PF07974
PF00047

PRINTS

PIRSF

SMART

SM00181
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q6PAP2

UniProt Splice Variant

Entrez Gene

21846

UniGene

RefSeq

MGI ID

MGI Symbol

Tie1

OMIM

CCDS

HPRD

IMGT

EMBL

AL627212 BC057004 BC060182

GenPept

AAH57004 AAH60182