InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIAPH2

Summary

InnateDB Protein

IDBP-78971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIAPH2

Protein Name

diaphanous homolog 2 (Drosophila)

Synonyms

DIA; DIA2; DRF2; POF; POF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000348082

InnateDB Gene

IDBG-78961 (DIAPH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0007015	actin filament organization
GO:0007292	female gamete generation
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR010465 DRF autoregulatory
IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold

PFAM

PF06345
PF06367
PF06371
PF02181

PRINTS

PIRSF

SMART

SM00498

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite