Version 5.4
Homo sapiens Gene: DIAPH2
Summary
InnateDB Gene IDBG-78961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIAPH2
Gene Name diaphanous homolog 2 (Drosophila)
Synonyms DIA; DIA2; DRF2; POF; POF2
Species Homo sapiens
Ensembl Gene ENSG00000147202
Encoded Proteins
IDBP-78963
diaphanous homolog 2 (Drosophila)
IDBP-78965
diaphanous homolog 2 (Drosophila)
IDBP-78967
diaphanous homolog 2 (Drosophila)
IDBP-78969
diaphanous homolog 2 (Drosophila)
IDBP-78971
diaphanous homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:96684663-97604997
Strand Forward strand
Band q21.33
Transcripts
ENST00000373061 ENSP00000362152
ENST00000324765 ENSP00000321348
ENST00000373054 ENSP00000362145
ENST00000373049 ENSP00000362140
ENST00000355827 ENSP00000348082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0000910 cytokinesis
GO:0007015 actin filament organization
GO:0007275 multicellular organismal development
GO:0007292 female gamete generation
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0048477 oogenesis
Cellular Component
GO:0005769 early endosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034480
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt O60879
TrEMBL A6NML8 K4DI95
UniProt Splice Variant
Entrez Gene 1730
UniGene Hs.226483
RefSeq NM_006729 NM_007309
HUGO HGNC:2877
OMIM 300108
CCDS CCDS14467 CCDS14468
HPRD
IMGT
EMBL AL031053 AL139399 AL139809 AL161624 AL391821 AL592157 AL606530 AL669876 CH471115 Y15908 Y15909 Z86061
GenPept CAA75869 CAA75870 CAB39108 CAD13477 CAH71113 CAH71114 CAH71361 CAI39841 CAI39842 CAI39928 CAI40544 CAI40545 CAI40915 CAI40916 CAI42257 CAI42258 CAI42515 EAX02791 EAX02793
RNA Seq Atlas 1730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca