Version 5.4
Mus musculus Protein: Ddx5
Summary
InnateDB Protein IDBP-789831.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddx5
Protein Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Synonyms 2600009A06Rik; G17P1; Hlr1; HUMP68; p68;
Species Mus musculus
Ensembl Protein ENSMUSP00000138237
InnateDB Gene IDBG-213550 (Ddx5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 147 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 147 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0019899 enzyme binding
GO:0030331 estrogen receptor binding
GO:0036002 pre-mRNA binding
GO:0048306 calcium-dependent protein binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0001701 in utero embryonic development
GO:0006200 ATP catabolic process
GO:0007623 circadian rhythm
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045069 regulation of viral genome replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060765 regulation of androgen receptor signaling pathway
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:105037
InterPro IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL S4R1I6
UniProt Splice Variant
Entrez Gene 13207
UniGene
RefSeq
MGI ID
MGI Symbol Ddx5
OMIM
CCDS
HPRD
IMGT
EMBL AL603664 CH466558 X94313
GenPept CAA63974 EDL34312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca