InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atg7

Summary

InnateDB Protein

IDBP-790151.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atg7

Protein Name

autophagy related 7

Synonyms

1810013K23Rik; Agp7; Apg7l; Atg7l; Gm21553;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000138651

InnateDB Gene

IDBG-178961 (Atg7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0005515	protein binding
GO:0019778	Atg12 activating enzyme activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001889	liver development
GO:0006497	protein lipidation
GO:0006520	cellular amino acid metabolic process
GO:0006914	autophagy
GO:0006996	organelle organization
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0009267	cellular response to starvation
GO:0009791	post-embryonic development
GO:0010508	positive regulation of autophagy
GO:0015031	protein transport
GO:0016239	positive regulation of macroautophagy
GO:0016567	protein ubiquitination
GO:0021680	cerebellar Purkinje cell layer development
GO:0021860	pyramidal neuron development
GO:0021955	central nervous system neuron axonogenesis
GO:0021987	cerebral cortex development
GO:0030163	protein catabolic process
GO:0031175	neuron projection development
GO:0031396	regulation of protein ubiquitination
GO:0031401	positive regulation of protein modification process
GO:0032446	protein modification by small protein conjugation
GO:0039689	negative stranded viral RNA replication
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0050877	neurological system process
GO:0055013	cardiac muscle cell development
GO:0061024	membrane organization
GO:0071455	cellular response to hyperoxia

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005737	cytoplasm
GO:0005930	axoneme

Protein Structure and Domains

PDB ID

MGI:1921494

InterPro

IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
IPR009036 Molybdenum cofactor biosynthesis, MoeB

PFAM

PF00899

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D906

PhosphoSite