InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam15

Summary

InnateDB Protein

IDBP-790207.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam15

Protein Name

a disintegrin and metallopeptidase domain 15 (metargidin)

Synonyms

MDC15; metargidin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139147

InnateDB Gene

IDBG-163900 (Adam15)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001525	angiogenesis
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0030574	collagen catabolic process
GO:0042246	tissue regeneration
GO:0060317	cardiac epithelial to mesenchymal transition

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005912	adherens junction
GO:0016021	integral component of membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:1333882

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt