InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC35C2

Summary

InnateDB Protein

IDBP-79033.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35C2

Protein Name

solute carrier family 35, member C2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318960

InnateDB Gene

IDBG-79031 (SLC35C2)

Protein Structure

UniProt Annotation

Function

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269PubMed:20837470}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:20837470}.

Disease Associations

Tissue Specificity

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006810	transport
GO:0010629	negative regulation of gene expression
GO:0036065	fucosylation
GO:0036066	protein O-linked fucosylation
GO:0045747	positive regulation of Notch signaling pathway
GO:0055085	transmembrane transport