Version 5.4
Homo sapiens Protein: SLC35C2
Summary
InnateDB Protein IDBP-79035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35C2
Protein Name solute carrier family 35, member C2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361304
InnateDB Gene IDBG-79031 (SLC35C2)
Protein Structure
UniProt Annotation
Function May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269PubMed:20837470}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:20837470}.
Disease Associations
Tissue Specificity Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005801 cis-Golgi network
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004853 Triose-phosphate transporter domain
IPR013657 UAA transporter
PFAM PF03151
PF08449
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQQ7
PhosphoSite PhosphoSite-Q9NQQ7
TrEMBL
UniProt Splice Variant
Entrez Gene 51006
UniGene Hs.742147
RefSeq NP_057029
HUGO HGNC:17117
OMIM
CCDS CCDS13396
HPRD 15371
IMGT
EMBL AF132949 AF455052 AL133227 BC014191 BC021138 BC025277 CH471077
GenPept AAD27724 AAH14191 AAH21138 AAH25277 AAL59605 CAC00659 CAI40552 EAW75747 EAW75748 EAW75750 EAW75751 EAW75752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca