InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABI2

Summary

InnateDB Protein

IDBP-79072.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABI2

Protein Name

abl-interactor 2

Synonyms

ABI-2; ABI2B; AblBP3; AIP-1; argBP1; argBPIA; argBPIB; SSH3BP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000261016

InnateDB Gene

IDBG-79064 (ABI2)

Protein Structure

UniProt Annotation

Function

May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. {ECO:0000269PubMed:10498863, ECO:0000269PubMed:7590236, ECO:0000269PubMed:8649853}.

Subcellular Localization

Cytoplasm {ECO:0000250}.Isoform 1: Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0019900	kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0008154	actin polymerization or depolymerization
GO:0016477	cell migration
GO:0016601	Rac protein signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation