Version 5.4
Homo sapiens Gene: ABI2
Summary
InnateDB Gene IDBG-79064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABI2
Gene Name abl-interactor 2
Synonyms ABI-2; ABI2B; AblBP3; AIP-1; argBP1; argBPIA; argBPIB; SSH3BP2
Species Homo sapiens
Ensembl Gene ENSG00000138443
Encoded Proteins
IDBP-79066
abl-interactor 2
IDBP-79068
abl-interactor 2
IDBP-79070
abl-interactor 2
IDBP-79072
abl-interactor 2
IDBP-388462
abl-interactor 2
IDBP-388463
abl-interactor 2
IDBP-388464
abl-interactor 2
IDBP-388465
abl-interactor 2
IDBP-388466
abl-interactor 2
IDBP-388467
abl-interactor 2
IDBP-388468
abl-interactor 2
IDBP-388469
abl-interactor 2
IDBP-388470
abl-interactor 2
IDBP-388471
abl-interactor 2
IDBP-388472
abl-interactor 2
IDBP-388476
abl-interactor 2
IDBP-388478
abl-interactor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:203328219-203447723
Strand Forward strand
Band q33.2
Transcripts
ENST00000376135
ENST00000261017 ENSP00000261017
ENST00000295851 ENSP00000295851
ENST00000261018 ENSP00000261018
ENST00000261016 ENSP00000261016
ENST00000447762 ENSP00000397850
ENST00000441061 ENSP00000410509
ENST00000416001 ENSP00000405801
ENST00000430418 ENSP00000408898
ENST00000425253 ENSP00000399040
ENST00000424558 ENSP00000391433
ENST00000413635 ENSP00000405255
ENST00000431886 ENSP00000408334
ENST00000444584 ENSP00000398487
ENST00000417864 ENSP00000414703
ENST00000422511 ENSP00000396249
ENST00000411547
ENST00000430574
ENST00000451591 ENSP00000413375
ENST00000422719
ENST00000454023 ENSP00000404352
ENST00000416396
ENST00000494215
ENST00000464761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0048365 Rac GTPase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007611 learning or memory
GO:0008154 actin polymerization or depolymerization
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043010 camera-type eye development
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005913 cell-cell adherens junction
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030425 dendrite
GO:0031209 SCAR complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000026782
View Gene Order
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.471156 Hs.645144
RefSeq NM_001282925 NM_001282926 NM_001282927 NM_001282932 NM_005759 XM_006712175 XM_006712180
HUGO
OMIM
CCDS CCDS2358 CCDS63093 CCDS63094 CCDS74634
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca