InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRPX2

Summary

InnateDB Protein

IDBP-79194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPX2

Protein Name

sushi-repeat containing protein, X-linked 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362095

InnateDB Gene

IDBG-79192 (SRPX2)

Protein Structure

UniProt Annotation

Function

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. {ECO:0000269PubMed:16497722, ECO:0000269PubMed:18718938, ECO:0000269PubMed:19065654, ECO:0000269PubMed:24179158}.

Subcellular Localization

Secreted. Cytoplasm. Cell surface. Cell junction, synapse {ECO:0000250}.

Disease Associations

Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX) [MIM:300643]: A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention. {ECO:0000269PubMed:16497722}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa. {ECO:0000269PubMed:16497722, ECO:0000269PubMed:18718938, ECO:0000269PubMed:19065654, ECO:0000269PubMed:22242148, ECO:0000269PubMed:9864177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0036458	hepatocyte growth factor binding
GO:0042802	identical protein binding

Biological Process

GO:0001525	angiogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0042325	regulation of phosphorylation
GO:0048870	cell motility
GO:0051965	positive regulation of synapse assembly
GO:0071625	vocalization behavior
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis