InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYTL4

Summary

InnateDB Protein

IDBP-79212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYTL4

Protein Name

synaptotagmin-like 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263033

InnateDB Gene

IDBG-79206 (SYTL4)

Protein Structure

UniProt Annotation

Function

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0042043	neurexin family protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0071985	multivesicular body sorting pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0019898	extrinsic component of membrane
GO:0030658	transport vesicle membrane