Version 5.4
Homo sapiens Gene: SYTL4
Summary
InnateDB Gene IDBG-79206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYTL4
Gene Name synaptotagmin-like 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102362
Encoded Proteins
IDBP-79208
synaptotagmin-like 4
IDBP-79210
synaptotagmin-like 4
IDBP-79212
synaptotagmin-like 4
IDBP-79214
synaptotagmin-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:100674491-100732123
Strand Reverse strand
Band q22.1
Transcripts
ENST00000372989 ENSP00000362080
ENST00000276141 ENSP00000276141
ENST00000263033 ENSP00000263033
ENST00000372981 ENSP00000362072
ENST00000491602
ENST00000491326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008270 zinc ion binding
GO:0017137 Rab GTPase binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0045921 positive regulation of exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0050714 positive regulation of protein secretion
GO:0071985 multivesicular body sorting pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031255
View Gene Order
ENSBTAG00000005724
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592224 Hs.660496 Hs.736401
RefSeq NM_001129896 NM_001174068 NM_080737 XM_005262226 XM_005262229 XM_006724717 XM_006724718
HUGO
OMIM
CCDS CCDS14472
HPRD 06735
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca