InnateDB Protein
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IDBP-79214.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYTL4
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Protein Name
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synaptotagmin-like 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362072
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InnateDB Gene
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IDBG-79206 (SYTL4)
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Protein Structure
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Function |
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010911
Zinc finger, FYVE-type
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
PF02318
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96C24
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PhosphoSite |
PhosphoSite-Q96C24
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
94121
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UniGene |
Hs.736401
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RefSeq |
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HUGO |
HGNC:15588
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OMIM |
300723
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CCDS |
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HPRD |
06735
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IMGT |
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EMBL |
AK094110
AL391688
AL832596
BC014913
BX537410
Z73900
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GenPept |
AAH14913
BAC04287
CAD97652
CAI42004
CAI42005
CAI46126
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