InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LSM2

Summary

InnateDB Protein

IDBP-79229.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LSM2

Protein Name

LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364813

InnateDB Gene

IDBG-79227 (LSM2)

Protein Structure

UniProt Annotation

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	64 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017070	U6 snRNA binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
IPR016654 U6 snRNA-associated Sm-like protein LSm2

PFAM

PF01423

PRINTS

PIRSF

PIRSF016394

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt